PrenaTest (PrenatalSafe 3 –trisomy 21/13/18)

Please note that independent interpretation of the results is not allowed; the information provided below is for reference only.
This test is performed only after consultation with a physician.

Prenatest (PrenatalSafe 3) is a non-invasive prenatal screening test designed to assess the risk of trisomies 21, 13, and 18 in the fetus. The test analyzes cell-free fetal DNA (cfDNA) present in maternal blood, providing highly accurate results without the need for invasive procedures such as amniocentesis or chorionic villus sampling.

Trisomy 21 (Down syndrome) occurs due to an extra copy of chromosome 21 and is characterized by distinct facial features, developmental delays, and an increased risk of cardiac and endocrine disorders. The main cause is meiotic error, most often maternal, as well as age-related and genetic factors.

Trisomy 13 (Patau syndrome) results from an extra copy of chromosome 13, leading to severe congenital malformations, including defects of the heart, central nervous system, and face. Most cases are associated with high perinatal mortality.

Trisomy 18 (Edwards syndrome) is caused by an extra copy of chromosome 18, characterized by multiple internal organ malformations, growth retardation, and low survival rates in newborns.

Prenatest 3 allows assessment of the probability of these trisomies as early as the 10th week of pregnancy, giving the patient the opportunity to make informed decisions regarding further diagnostic steps and monitoring.

Indications

• Pregnant women over 35 years old
• History of previous pregnancies with chromosomal abnormalities
• Increased risk based on biochemical or ultrasound screening results
• Patients seeking an accurate and safe assessment of trisomy 21, 13, and 18 risk
• Genetic factors increasing the likelihood of chromosomal abnormalities

Procedure

• Collection of venous blood from the pregnant woman (usually from the cubital vein).
• Fetal DNA is extracted from maternal plasma and subjected to molecular genetic analysis.
• Test results are evaluated as a probabilistic estimate of the presence of trisomies 21, 13, and 18.
• The obtained data are interpreted by a genetic specialist and communicated to the patient along with recommendations for further steps.

This service is available at the following branches: Chișinău, 64/2 Albișoara Street, 19/1 Testemițanu Street, and Bălți, 126 Decebal Street.
 

Sources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686697/
https://pubmed.ncbi.nlm.nih.gov/32166736/
https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.14664
https://www.stanfordchildrens.org/en/topic/default?id=trisomy-18-and-13-90-P02419

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or treatment. If you experience any discomfort or exacerbation of a condition, it is essential to consult a healthcare professional for appropriate diagnostic testing and treatment. Only a qualified specialist can make an accurate diagnosis and determine the appropriate treatment. To obtain the most accurate and consistent assessment of test results, it is recommended to have them performed at the same laboratory. This is because different laboratories may use different methods and units of measurement for similar tests.